PRCC (papillary renal cell carcinoma)

Identity

Other names	RCCP1 (renal cell carcinoma, papillary, 1)
HGNC	PRCC
Location	1q21.2
Location_base_pair	Starts at 155003898 and ends at 155037233 bp from pter ( according to hg18-Mar_2006).

DNA/RNA

Description	cDNA of 2039 bp
Transcription	1989 bp RNA; coding sequence: CDS 191...1666

Protein

Description	491 amino acids; 52 kDa; proline/leucine/glycine rich domain of 150 amino acids in N-term
Expression	wide; in the fetus and in the adult
Homology	none is known

Implicated in

Entity	t(X;1)(p11.2;q21.2) in renal cell carcinoma --> PRCC/TFE3
Disease	t(X;1) is a very rare subtype of papillary renal cell carcinoma
Prognosis	overall 5-yr survival rate around 85%
Hybrid/Mutated Gene	5' PRCC- 3' TFE3; variable breakpoint in PRCC; breakpoint in the 1st intron of TFE3
Abnormal Protein	N-term PRCC with the proline rich sequence fused to most of TFE3, including the ; the reciprocal TFE3-PRCC is expressed; it is to be noted that the normal TFE3 transcript is lost in female patients.

External links

	Nomenclature
HGNC	PRCC   9343
Entrez_Gene	PRCC  5546  papillary renal cell carcinoma (translocation-associated)
	Cards
Atlas	PRCCID69
GeneCards	PRCC
Ensembl	PRCC [Search_View]   ENSG00000143294 [Gene_View]  PRCC [Vega]
Genatlas	PRCC
GeneLynx	PRCC
eGenome	PRCC
euGene	5546
	Genomic and cartography
GoldenPath	PRCC  -  1q21.2   chr1:155003898-155037233 +  1q21.1   [Description]    (hg18-Mar_2006)
Ensembl	PRCC - 1q21.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	PRCC
	Gene and transcription
Genbank	AA846273 [ ENTREZ ]
Genbank	AK126403 [ ENTREZ ]
Genbank	AK289872 [ ENTREZ ]
Genbank	BC004913 [ ENTREZ ]
Genbank	BC010450 [ ENTREZ ]
RefSeq	NM_005973 [ SRS ]    NM_005973 [ ENTREZ ]
RefSeq	NM_199416 [ SRS ]    NM_199416 [ ENTREZ ]
RefSeq	AC_000044 [ SRS ]    AC_000044 [ ENTREZ ]
RefSeq	AC_000133 [ SRS ]    AC_000133 [ ENTREZ ]
RefSeq	NC_000001 [ SRS ]    NC_000001 [ ENTREZ ]
RefSeq	NG_008138 [ SRS ]    NG_008138 [ ENTREZ ]
RefSeq	NT_004487 [ SRS ]    NT_004487 [ ENTREZ ]
RefSeq	NW_001838531 [ SRS ]    NW_001838531 [ ENTREZ ]
RefSeq	NW_925683 [ SRS ]    NW_925683 [ ENTREZ ]
CCDS	PRCC CCDS - NCBI
AceView	PRCC AceView - NCBI
Unigene	Hs.516948 [ SRS ]    Hs.516948 [ NCBI ]     HS516948 [ spliceNest ]
Fast-db	17414 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q5SZ06 [ SRS]    Q5SZ06 [ EXPASY ]     Q5SZ06 [ INTERPRO ]     Q5SZ06 [ UNIPROT ] Q5SZ06 [ VarSplice ]
CluSTr	Q5SZ06
Blocks	Q5SZ06
HPRD	01562
	Protein Interaction databases
DIP	Q5SZ06
IntAct	Q5SZ06
	Polymorphism : SNP, mutations, diseases
OMIM	179755;605074    [ map ]
GENECLINICS	179755;605074
SNP	PRCC [dbSNP-NCBI]
SNP	NM_005973 [SNP-NCI]
SNP	NM_199416 [SNP-NCI]
SNP	PRCC [GeneSNPs - Utah]  PRCC] [HGBASE - SRS]
HAPMAP	PRCC [HAPMAP]
COSMIC	PRCC [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	PRCC
Genetic Association	PRCC
CDC HuGE	PRCC
	General knowledge
Family Browser	PRCC [UCSC Family Browser]
SOURCE	NM_005973
SOURCE	NM_199416
SMD	Hs.516948
SAGE	Hs.516948
GO	molecular_function [Amigo]  molecular_function
GO	cellular_component [Amigo]  cellular_component
GO	biological_process [Amigo]  biological_process
PubGene	PRCC
TreeFam	PRCC
CTD	5546 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PRCC Related clones (RZPD - Berlin)
	PubMed
PubMed	13 Pubmed reference(s) in Entrez

Bibliography

The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene.

Sidhar SK, Clark J, Gill S, Hamoudi R, Crew AJ, Gwilliam R, Ross M, Linehan WM, Birdsall S, Shipley J, Cooper CS

Human molecular genetics. 1996 ; 5 (9) : 1333-1338.

PMID 8872474

Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas.

Weterman MA, Wilbrink M, Geurts van Kessel A

Proceedings of the National Academy of Sciences of the United States of America. 1996 ; 93 (26) : 15294-15298.

PMID 8986805

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	01-1999	Fran¨ois Desangles and Jean-Loup Huret

Citation

This paper should be referenced as such :

Desangles F and Huret JL . PRCC (papillary renal cell carcinoma). Atlas Genet Cytogenet Oncol Haematol. January 1999 . URL : http://AtlasGeneticsOncology.org/Genes/PRCCID69.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sun Nov 9 19:45:50 2008