Atlas of Genetics and Cytogenetics in Oncology and Haematology
TAL1 (T-cell acute leukemia 1)
| Identity |
| Other names | SCL (stem cell leukaemia), TCL5 (T cell leukaemia 5) |
| HGNC | TAL1 |
| Location | 1p32 |
| Location_base_pair | Starts at 47454551 and ends at 47468030 bp from pter ( according to hg18-Mar_2006). |
| DNA/RNA |
 | |
| DNA diagram | |
| Description | 8 exons; 16 kb; SIL (a different gene) sits 90 kb further in 5' |
| Transcription | (complex) alternate splicing of: 1A with 2A, or 3 vs 1B, 2B,3 ...or directly 4, 5, 6 |
| Protein |
| Description | 331 amino acids for the major form of 48 KDa; a truncated form of 26 KDa only in some T-ALL; domains: prolin rich in N-trem; poly Gly; basic Helix-Loop-Helix from the exon 6. |
| Expression | in hematopoietic stem cells, erythroid and megakaryocytic lineages of the adult and in the embryonic brain; indispensable for the genesis of the hematopoietic system. |
| Function | transcription factor; exhibits sequence-specific DNA binding activity when in dimers with another bHLH protein such as E2A (DNA specific sequences are: CANNTG, especially: CAGATG); direct interactions of the bHLH with the LIM domain of RBTN2 or RBTN1. |
| Homology | TAL2 in 9q32; LYL1 in 19p13; more distantly: MYC and other members of the MYC family of Helix-Loop-Helix transcription factors. |
| Implicated in |
| Entity | t(1;7)(p32;q34) or t(1;14)(p32;q11)/T-ALL --> TAL1-TCRB or TAL1-TCRD |
| Disease | T-cell ALL |
| Prognosis | is not too poor, compared to other T-ALL |
| Entity | T-ALL with normal karyotype, but with submicroscopic deletions of part of TAL1 in the 5' region --> SIL-TAL1. |
| Disease | found in 10 to 30 % of T-ALL with a normal karyotype |
| Hybrid/Mutated Gene | deletions which place SIL (SCL interrupting sequence) in close 5' of TAL1; hybrid gene with exon 1 from SIL. |
| Abnormal Protein | TAL1 is under the promoter sequences controle of SIL, a gene active during T cell development. |
| Entity | t(1;3)(p32;p21)/T-ALL --> TAL1-TCTA |
| Disease | T-cell ALL |
| Breakpoints |
 | |
| Note | mainly in 5' in a 1 kb region; but also dispersed in rare cases |
| External links |
| Bibliography |
| Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. |
| Ono Y, Fukuhara N, Yoshie O |
| The Journal of biological chemistry. 1997 ; 272 (7) : 4576-4581. |
| PMID 9020185 |
| The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation. |
| Hofmann TJ, Cole MD |
| Oncogene. 1996 ; 13 (3) : 617-624. |
| PMID 8760303 |
| The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. |
| Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW, Orkin SH |
| Cell. 1996 ; 86 (1) : 47-57. |
| PMID 8689686 |
| Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. |
| Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH |
| Proceedings of the National Academy of Sciences of the United States of America. 1995 ; 92 (21) : 9585-9589. |
| PMID 7568177 |
| Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. |
| Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R |
| The EMBO journal. 1994 ; 13 (20) : 4831-4839. |
| PMID 7957052 |
| Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study. |
| Bash RO, Crist WM, Shuster JJ, Link MP, Amylon M, Pullen J, Carroll AJ, Buchanan GR, Smith RG, Baer R |
| Blood. 1993 ; 81 (8) : 2110-2117. |
| PMID 8471769 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 08-1997 | Jean-Loup Huret and Marie-Claude Labastie |
| - | ||
| Updated | 03-1998 | Jean-Loup Huret and Marie-Claude Labastie |
| Institut d'Embryologie Cellulaire et Moléculaire, CNRS FRE 216O, 94736, Nogent-sur-Marne Cedex, France |
| Citation |
| This paper should be referenced as such : |
| - . TAL1 (T-cell acute leukemia 1). Atlas Genet Cytogenet Oncol Haematol. August 1997 . URL : http://AtlasGeneticsOncology.org/Genes/TAL1.html |
| Huret JL and Labastie MC . TAL1 (T-cell acute leukemia 1). Atlas Genet Cytogenet Oncol Haematol. March 1998 . URL : http://AtlasGeneticsOncology.org/Genes/TAL1.html |
| Huret JL and Labastie MC . TAL1 (T-cell acute leukemia 1). Atlas Genet Cytogenet Oncol Haematol. . URL : http://AtlasGeneticsOncology.org/Genes/TAL1.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sun Nov 9 19:48:17 2008 |
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