Atlas of Genetics and Cytogenetics in Oncology and Haematology
| CASE REPORTS in HAEMATOLOGY |
| A case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32) |
| Petr Balicek, Jana Rabasova, Jiri Hak |
| Clinics |
| Age and sex : | 17 year(s) old male patient. |
| Previous History : | no preleukemia |
| no previous malignant disease | |
| Organomegaly : | no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement |
| Blood |
| WBC : 32.9 x 109/l; Hb : 7.7 g/dl; platelets : 9 x 109/l; blasts : 90% |
| Cyto pathology classification |
| Cytology : ALL - L1 |
| Immunophenotype : CD10 (CALLA) positive; CD66 positive |
| Precise diagnosis : Early pre-B ALL |
| Survival |
| Date of diagnosis: 04-2001 |
| Treatment : Treated on protocol BFM 95 - medium risk group. |
| Complete remission was obtained |
| Comments : second cytogenetic examination: 47,XY,+21[70] - complete cytogenetic response. |
| Status : Dead |
| Survival : 1 month(s) |
| Karyotype |
| Sample : bone marrow ; culture time : 24 h ; banding : R |
| Results : 47,XY, der(14)t(8;14)(q11;q32),+21 "c" [17]/47,XY,+21 "c" [3] |
 |
| der(14) t(8;14)(q11;q32) R- banding; the constitutional trisomy 21 is shown only on the bottom mitosis (left); chromosome 8 paint (right) - Petr Balicek, Jana Rabasova, Jiri Hak. |
| Call for collaboration |
| - Both bone marrow samples are stored: Bone marrow cell suspension, isolated RNA and DNA from the first examination you can get at address: Dr. Jan Trka - jan.trka@lfmotol.cuni.cz - Isolated nucleic acids (both RNA and DNA) and cDNA from the second examination are available at the address below: Dr. Zdenek Fiedler - fiedler@lfhk.cuni.cz |
| Internal links |
| Atlas Card | t(8;14)(q11;q32) |
| Case Report | A case of pre-B ALL with t(8;14)(q11;q32). |
| Case Report | A new case of t(8;14)(q11;q32) in an acute lymphoblastic leukemia |
| Bibliography |
| Two Down syndrome patients with an acquired translocation, t(8;14)(q11;q32), in early B-lineage acute lymphoblastic leukemia. |
| Secker-Walker LM, Hawkins JM, Prentice HG, Mackie PH, Heerema NA, Provisor AJ |
| Cancer genetics and cytogenetics. 1993 ; 70 (2) : 148-150. |
| PMID 8242599 |
| Down syndrome, acute lymphoblastic leukemia, and t(8;14)(q11;q32) |
| Lee AC, Chan LC, Kwong KW |
| Cancer genetics and cytogenetics. 1996 ; 88 (1) : page 92. |
| PMID 8630990 |
| t(8;14)(q11;q32). Atlas Genet Cytogenet Oncol Haematol. November 1999 |
| Huret JL |
| URL.. |
| Acute lymphoblastic leukemia with an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group Study. |
| Kaleem Z, Shuster JJ, Carroll AJ, Borowitz MJ, Pullen DJ, Camitta BM, Zutter MM, Watson MS |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2000 ; 14 (2) : 238-240. |
| PMID 10673739 |
| Relationship of chromosome 21 and acute leukemia in children with Down syndrome. |
| Taub JW |
| Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology. 2001 ; 23 (3) : 175-178. |
| PMID 11305722 |
| Contributor(s) |
| Written | 06-2001 | Petr Balicek, Jana Rabasova, Jiri Hak |
| Citation |
| This paper should be referenced as such : |
| Balicek P, Rabasova J, Hak J . A case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32). Atlas Genet Cytogenet Oncol Haematol. June 2001 . URL : http://AtlasGeneticsOncology.org/Reports/t814BalicekID100002.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Sep 24 21:09:54 2008 |
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